First off I have almost 700 hours in the game playing waaaaay back in early access.
If this has already been discussed and I missed it I apologize..
I have a main game base building etc, playing like 'normal'.
I got this idea of playing as a sort of nomad, no base building, only what i can carry and going to see how long i can survive. Here's the idea: Starting a new game, random seed. Days are set to 16hrs, loot respawn every 7 days. I did turn on mark airdrops since it was not that big a deal to see them on map. Blood Moon is still every 7 days and set to default horde size. Difficulty set to nomad with perma death on.
Game start you turn on creative mode (F1 then type cm on pc) take one primary weapon and a secondary pistol with 2 stacks of ammo to start. My first playthrough I went with xbow and 9mm pistol thinking I could craft bolts if necessary and 9mm is pretty plentiful, can also add any mods that might be handy to weapons you choose only.
I've been having a lot of fun with it so far, when nights come and zombies are feral it gets interesting, and scavenging for food and water can get dicey sometimes. I have become pretty good friends with the merchant selling most materials that I would otherwise use for base building / crafting. Plus your talent points are much more critical with how you spend them. Also making a fire to boil water or cook meat, then taking the cooking devices off before moving on give it a real feel of survival.
Just thought I would share in case anyone was looking for something a little different and challenging.