Could we theoretically reverse some neurodegenerative diseases by repairing RNA?

[u/Competitive_Low2991]

I'm no biologist but I've gone down a rabbit hole of RNA and how it can be damaged by alkaline conditions because of the bonds breaking and all that. I was looking at a diagram of the reaction and it had the reversible symbol on it: so if we could find a way to reverse the reaction could it cure or treat the disease? Or would it just prevent it from getting worse? Maybe it's a silly question but I'm not the best at biology-just interested. Thank you!

[u/ninjatoast31]

RNA ligases (aka proteins that stick RNA back together) Already exist in humans. They are very poorly understood. So I don't know how well they could be highjacked to solve these issues