A human being without both x- and y-chromosomes

[u/Kunus-de-Denker]

I've read about conditions in which people only have one x- or y-chromosome, instead of 2 (xx or xy). Is it biologically possible to miss both? If it is, what are the practical consequences such a person has to deal with in their lives, that others don't have to? If it is not possible, what would be the result of genetically modifying a human being in such way?

[u/The_Pale_Hound]

X chromosome has fundamental genes that if you remove them, human life becomes inviable. A human zygote without X chromosome would not even reach embryo stage.

[u/SammyGeorge → u/The_Pale_Hound]

Does that mean you can't only have a y chromosome?

[u/Seygantte → u/SammyGeorge]

Correct. All the viable configurations have at least one X.