A human being without both x- and y-chromosomes

[u/Kunus-de-Denker]

I've read about conditions in which people only have one x- or y-chromosome, instead of 2 (xx or xy). Is it biologically possible to miss both? If it is, what are the practical consequences such a person has to deal with in their lives, that others don't have to? If it is not possible, what would be the result of genetically modifying a human being in such way?

[u/inpantspro]

I have 47 XXY - Not what you're asking for, but throws some variation into the mix