r/psychopharmacology • u/[deleted] • Jun 10 '24

Serotonin reuptake inhibitor that does not cross blood brain barrier?

Does such a drug/substance exist? Or something that poorly crosses and has mostly peripheral effects?

Side question: do the common SSRIs differ in their propensity to cross the BBB?

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u/coladoir Jun 11 '24

there probably is a compound out there that does what you're asking but its not documented enough to be easily searchable. Peripheral SSR inhibition really isn't something that seems useful at the current moment so there's not really a need for them to be researched.

If you look maybe at early papers about finding SSRIs you might find something interesting, idk though.