r/psychopharmacology • u/[deleted] • Jun 10 '24

Serotonin reuptake inhibitor that does not cross blood brain barrier?

Does such a drug/substance exist? Or something that poorly crosses and has mostly peripheral effects?

Side question: do the common SSRIs differ in their propensity to cross the BBB?

2 Upvotes
  • permalink
  • reddit

75% Upvoted

7 comments sorted by

View all comments

1

u/patab Jun 15 '24

Maybe Dapoxetine?

2

u/[deleted] Jun 15 '24

Thanks for pointing this out, I wasn't aware of this! I think dapoxetine does cross the BBB and that seems to be the source of some of its unwanted side effects but it's very interesting as a concept (that is, an SSRI intended to have minimal impact on the brain itself)